货号：07-1353

品牌：Merck Millipore

规格：100Ug

目录价：￥4502.00

市场价格：￥3826.70

会员价格：￥3601.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-lysine EPOR (Lys373) Antibody | 07-1353 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes EPOR acetylated at Lys373. View All» Molecular Weight: ~59 kDa observed. The calculated molecular weight of this protein is 55 kDa, but has been observed at ~59 kDa due to glycosolation. Uncharacterized bands at ~17, 40, 58, and 160 kDa may be observed in some lysates. View All» Epitope: Acetylated Lys373 View All» Immunogen: KLH-conjugated linear peptide corresponding to human EPOR acetylated at Lys373. View All» Modifications: Acetylation View All» Background Information: EPOR is the receptor for erythropoietin and high expression has been associated with extended erythroblast proliferation and differentiation. EPOR and KIT work together to ensure normal erythroid cell expansion. EPOR has recently been found to interact will membrane-acting androgens to protect tumor cells from apoptosis. View All» Species Reactivity:

• Human

• Mouse

• Bovine

• Canine

• Pig
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse, Bovine, Canine, and Porcine based on 100% sequence homology. View All» Control: Sodium butyrate untreated and treated HeLa cell lysates View All» Quality Assurance: Evaluated by Western Blot in sodium butyrate untreated and treated HeLa cell lysates.Western Blot Analysis: 2 µg/mL of this antibody detected EPOR on 10 µg of sodium butyrate untreated and treated HeLa cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P19235 View All» Entrez Gene Number: NP_000112 View All» Gene Symbol: EPOR View All» Alternate Names:
  • Erythropoietin receptor

  • EPO-R
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.SUBUNIT STRUCTURE: Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN By similarity, the adapter protein APS, PTPN6 (By similarity), PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL By similarity. Interacts with INPP5D/SHIP1 (By similarity). The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2 (By similarity). APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11 (By similarity). Binding of JAK2 (through its N-terminal) promotes cell-surface expression (By similarity). Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Isoform EPOR-S: Secreted. Note: Secreted and located to the cell surface. TISSUE SPECIFICITY: Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.PTM: On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site. Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.INVOLVEMENT IN DISEASE: Defects in EPOR are the cause of erythrocytosis familial type 1 (ECYT1) [MIM:133100]. ECYT1 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin and hematocrit, hypersensitivity of erythroid progenitors to erythropoietin, erythropoietin low serum levels, and no increase in platelets nor leukocytes. It has a relatively benign course and does not progress to leukemia. SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain. View All» Product Name: Anti-acetyl-lysine EPOR (Lys373) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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