货号：07-1369

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RGS14 Antibody | 07-1369 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 62-64 kDa observed. UniProtKB/Swiss-Prot O43566 (RGS14_HUMAN) entry describes 4 isoforms produced by alternative splicing: Isoform 1 at 61.447 kDa, Isoform 2 at 21.781 kDa, Isoform 3 at 44.820 kDa, and Isoform 4 at 36.922 kDa. View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human RGS14. View All» Background Information: Regulator of G-protein signaling 14 (RGS14) belongs to the regulator of G protein signaling (RGS) family, a group of roughly 20 proteins that serve to negatively regulate signaling. RGS14 is comprised of a single GoLoco domain, two RBD or Ras-binding domains, and one RGS domain. With the RBD domains, RGS14 localizes to centrosomes. It functionally inhibits signal transduction through upregulation of Gα subunit GTPase activity, inactivating the subunits through their binding with GDP. Expression of RGS14 has been observed in various tissues, including brain, thymus and spleen. It has also been observed in certain cells such as lymphocytes, dendritic cells, monocytes, and lymphatic cell lines. View All» Species Reactivity:

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human based on 100% sequence homology. View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 5 µg/mL from a previous lot detected RGS14 on 10 µg of PC-12 cell lysate. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC-12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected RGS14 on 10 µg of PC-12 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O43566 View All» Entrez Gene Number: NP_006471 View All» Gene Symbol: RGS14 View All» Alternate Names:
  • regulator of G-protein signalling 14

  • regulator of G-protein signaling 14
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.SUBCELLULAR LOCATION: Membrane (By similarity). SEQUENCE SIMILARITIES: Contains 1 GoLoco domain.Contains 2 RBD (Ras-binding) domains.Contains 1 RGS domain.SEQUENCE CAUTION: The sequence AAB92614.1 differs from that shown. Reason: Frameshift at positions 337, 344, 348, 539 and 544. View All» Product Name: Anti-RGS14 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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