货号：07-1387

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-oxidized-CaM Kinase II (Met281/282) Antibody | 07-1387 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes CaM Kinase II when oxidized on Met281/282. View All» Molecular Weight: 60 kDa View All» Epitope: Oxidized Met281/282 View All» Immunogen: Synthetic peptide encompassing and including oxidized Met281/282. View All» Background Information: The Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV, Phosphorylase Kinase, and MLCK. The CaM Kinases are inactive in the absence of stimuli; binding to Ca2+/Calmodulin induces conformational changes and activation. CaM Kinases have broad substrate specificity, with many cellular functions. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human. Expected to cross-react on Mouse and Rat based on 100% homology with immunogen sequence. View All» Application Notes: An independent lab validated this antibody to work in immunocytochemistry in heart sections from mice treated with saline, AngII,or Iso (Erickson, J.R., 2008). View All» Quality Assurance: Evaluated by western blot on untreated and H2O2-treated mouse heart cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect oxidized CaM Kinase II in mouse heart cell lysates. View All» Presentation: Unpurified rabbit serum containing 0.05% NaN3. View All» Storage Conditions: Stable for 1 years at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q96RR4 View All» Entrez Gene Number: NP_742127 View All» Gene Symbol:
  • CAMKK

  • CAMKKB

  • EC 2.7.11.17

  • KIAA0787

  • MGC15254
    View All» Alternate Names:
    • CAMKK beta protein

    • CaM-KK beta

    • CaM-kinase kinase beta

    • CaMKK beta

    • Calcium/calmodulin-dependent protein kinase kinase beta

    • calcium/calmodulin-dependent protein kinase beta

    • calcium/calmodulin-dependent protein kinase kinase 2 beta

    • calcium/calmodulin-dependent protein kinase kinase 2, beta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain havedifferent expression patterns. View All» UniProt Summary: FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 By similarity.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.SUBUNIT STRUCTURE: Interacts with calmodulin By similarity.SUBCELLULAR LOCATION: CytoplasmBy similarity. TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.PTM: Autophosphorylated By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.SEQUENCE CAUTION: The sequence CAD38990.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. View All» Product Name: Anti-oxidized-CaM Kinase II (Met281/282) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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