货号：07-1389

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Smad3 (Ser423/425) Antibody | 07-1389 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: Detects phosphorylated Smad3 (Ser423 and Ser425). View All» Molecular Weight: 50 kDa View All» Epitope: Phosphorylated Ser423/425 View All» Immunogen: KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser423/425 of human Smad3. View All» Modifications: Phosphorylation View All» Background Information: Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5 and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression. View All» Species Reactivity:

• Mouse

• Mink

• Human

• Rat
  View All» Species Reactivity Note: Mouse and Mink. Predicted to react with Human and Rat based on sequence homology. View All» Quality Assurance: Evaluated by western blot on untreated and UV-treated AKR-2B cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect Smad3 in UV-treated AKR-2B cell lysate. View All» Presentation: Unpurified rabbit serum in buffer containing 0.05% sodium azide. View All» Storage Conditions: Stable for 2 years at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: P84022 View All» Entrez Gene Number: NM_005902 View All» Gene Symbol:
  • DKFZp586N0721

  • DKFZp686J10186

  • HSPC193

  • HsT17436

  • JV15-2

  • MADH3

  • MGC60396

  • Mad3

  • hMAD-3

  • hSMAD3
    View All» Alternate Names:
    • MAD, mothers against decapentaplegic homolog 3

    • MAD, mothers against decapentaplegic homolog 3 (Drosophila)

    • Mothers against DPP homolog 3

    • SMA- and MAD-related protein 3

    • SMAD 3

    • SMAD family member 3

    • SMAD, mothers against DPP homolog 3

    • SMAD, mothers against DPP homolog 3 (Drosophila)

    • mad homolog JV15-2

    • mad protein homolog

    • mothers against decapentaplegic homolog 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) By similarity.SUBUNIT STRUCTURE: Interacts with HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with TTRAP By similarity. Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4. Interacts with JUN/FOS, vitamin D receptor, homeobox protein TGIF and TGIF2, PEBP2-alpha C subunit, CREB-binding protein (CBP), p300, SKI, SNON, ATF2, SMURF2, AIP1, DACH1 and TGFB1I1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Found in a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Interacts with SMAD2 and TRIM33. Found in a complex with SMAD3, Ran and XPO4. Interacts with XPO4. Interacts with LBXCOR1 and CORL2.SUBCELLULAR LOCATION: CytoplasmBy similarity. NucleusBy similarity. Note= In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 By similarity.DOMAIN: The MH2 domain is sufficient to carry protein nuclear export.PTM: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases. INVOLVEMENT IN DISEASE: Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500].SEQUENCE SIMILARITIES: Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain. View All» Product Name: Anti-phospho-Smad3 (Ser423/425) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Host: Rabbit View All»
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