货号：07-1402

品牌：Merck Millipore

规格：EA

目录价：￥3850.00

市场价格：￥3272.50

会员价格：￥3080.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GLUT-2 Antibody | 07-1402 View All» Replaces: 07-1402 is a recommended replacement for AB1342 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes GLUT-2 in mouse, rat, and human tissues. View All» Molecular Weight: By Western blot, antibody recognizes a major band at approximately 57 kDa. View All» Immunogen: A 16 amino acid peptide sequence corresponding to the exoplasmic loop between helices 1 and 2 of rat liver Glucose Transporter coupled to KLH. View All» Isotype: IgG View All» Background Information: GLUTs (Glucose transporters) are a family of integral membrane proteins that facilitative glucose uptake by cells. They are integral membrane glycoproteins involved in transporting glucose into most cells. Seven types of glucose transport carrier proteins, designated as GLUT 1 to 7, facilitate glucose transport across the cell membrane. Molecular cloning of glucose transporters have identified a family of closely related genes that encode at least 7 proteins exhibiting high degree of amino acid homology (45% to 65%), all in the molecular weight range of 40 to 60 kDa. GLUT-1 functions in constitutive or basal glucose uptake in adult tissues and is the predominant glucose transporter in embryonic and fetal tissues. It has two forms, a 55kDa and a 45 kDa. The 55kDa form of GLUT1 regulates import of glucose from blood to brain across the endothelial cells of the blood-brain barrier (BBB), whereas the 45 kDa form of GLUT1 predominantly regulates nonvascular glial glucose uptake. GLUT2 is a facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. GLUT-4 is present in skeletal muscle, heart and adipose tissues. GLUT-4 is highly conserved between species. The expression of GLUT-4 is greatly influenced by insulin and other stimulators of the IP3 signaling pathway. Binding of insulin to the insulin receptor signals through PI3K and Akt to translocate GLUT-4 to the plasma membrane where it allows the uptake of glucose. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse, Rat View All» Application Notes: ELISA: A previous lot of this antibody was used on ELISA at 1:10,000 - 1:50,000 dilution.Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet View All» Control: HEK293 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HEK293 lysates. Western Blot Analysis: 1:500-1:1,500 dilution of this lot detected GLUT-2 on 10 µg of HEK293 lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal antiserum in buffer containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P11168 View All» Entrez Gene Number: NM_000340.1 View All» Gene Symbol:
  • SLC2A2

  • GLUT-2

  • GLUT2
    View All» Alternate Names:
    • Glucose Transporter type 2, liver

    • Solute carrier family 2, facilitated glucose transporter, member 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • ELISA
        View All» Entrez Gene Summary: Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Liver, insulin-producing beta cell, small intestine and kidney. PTM: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells (By similarity). DISEASE: Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily [view classification]. View All» Product Name: Anti-GLUT-2 Antibody | 07-1402 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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