货号：07-1414

品牌：Merck Millipore

规格：EA

目录价：￥3024.00

市场价格：￥2570.40

会员价格：￥2419.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Glycogen Synthase (muscle) (Ser640) Antibody | 07-1414 View All» Replaces: 07-1414 is a recommended replacement for AB3379. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Glycogen synthase (muscle), phosphoSer640. By Western blot the antibody recognizes the ~84 kDa phosphorylated protein. Reactivity to non-phosphorylated human Glycogen synthase is minimal (less than 0.2%) by ELISA. View All» Molecular Weight: Antibody recognizes the ~84 kDa phosphorylated protein. View All» Immunogen: Synthetic phospho peptide from human muscle Glycogen synthase. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: A glycosyltransferase enzyme that catalyses the reaction of UDP-glucose and (1,4-α-D-glucosyl)n to yield UDP and (1,4-α-D-glucosyl)n+1. In other words, this enzyme converts excess glucose residues one by one into a polymeric chain for storage as glycogen. The reaction is highly regulated by allosteric effectors such as glucose-6-phosphate, by phosphorylation reactions, and indirectly triggered by the hormone insulin. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and Mouse View All» Application Notes: Direct ELISA: 1:30,000-1:150,000 dilution of a previous lot was used in direct ELISA when assayed against 0.1 µg of the immunogen peptide.Optimal working dilutions must be determined by the end user.Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet. View All» Control: PDGF treated NIH/3T3 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on PDGF treated NIH/3T3 lysates.Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected phosphorylated Glycogen Synthase on 10 μg of PDGF treated NIH/3T3 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 0.02 M Potassium phosphate, pH 7.2 with 0.15 M Sodium chloride and 0.01% sodium azide. View All» Storage Conditions: Stable for 6 months at -20°C in undiluted aliquotes from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P13807 View All» Entrez Gene Number: NM_002103.3 View All» Gene Symbol:
  • GYS1

  • Glycogen

  • GYS

  • GSY
    View All» Alternate Names: Starchsynthase, muscle View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA
      View All» Entrez Gene Summary: Glycogen is a high molecular mass polysaccharide that serves as a repository of glucose for use in times of metabolic need. Glycogen synthase (EC 2.4.1.11) catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages (Pederson et al., 2004 [PubMed 15282316]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. CATALYTIC ACTIVITY: UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1). ENZYME REGULATION: Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity). PATHWAY: Glycan biosynthesis; glycogen biosynthesis. DISEASE: Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. SIMILARITY: Belongs to the mammalian/fungal glycogen synthase family. View All» Product Name: Anti-phospho-Glycogen Synthase (muscle) (Ser640) Antibody | 07-1414 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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