货号：07-1416

品牌：Merck Millipore

规格：

目录价：￥3615.00

市场价格：￥3072.75

会员价格：￥2892.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-4E-BP1 Antibody | 07-1416 View All» Replaces: 07-1416 is a recommended replacement for AB3251. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Eukaryotic translation initiation factor 4E binding protein (eIF4E Binding Protein, eIF4EBP1, 4E-BP1, 4EBP1). View All» Molecular Weight: 15-20 kDa View All» Immunogen: Synthetic peptide corresponding to a portion of human eIF4E Binding Protein encoded in part by exon 2 and 3. View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat

• Mouse

• Pig
  View All» Species Reactivity Note: Human, Rat, Mouse and Pig. View All» Application Notes: Immunohistochemisty (paraffin): 4E-BP1 representative staining pattern/morphology in thyroid cancer. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining pattern/morphology in thyroid cancer tissue.Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet. View All» Control: A431 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on A431 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected 4E-BP1 on 10 μg of A431 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing Tris-citrate/phosphate, pH 7-8, and 0.1% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt. View All» UniProt Number: Q13541 View All» Entrez Gene Number: NM_004095.3 View All» Gene Symbol:
  • EIF4EBP1

  • PHAS-I

  • MGC4316

  • 4E-BP1

  • 4EBP1

  • BP-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in sponse to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.[provided by RefSeq] View All» UniProt Summary: FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the eIF4E-binding protein family. View All» Product Name: Anti-4E-BP1 Antibody | 07-1416 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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