金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Val114-Gly281, with and without an N-terminal Met Accession #:Q6IBA9 N-terminal Sequence Analysis:Val114 Structure:Homotrimer Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:19 kDa (monomer) Activity:Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycinD. Matthews,N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 221.The ED₅₀ for this effect is typically0.5-6ng/mL. Note: This is one of multiple forms available for this protein. Check R&D Systems' website, www.RnDSystems.com, for a complete listing of the variants. Molecule Information: TRAIL/TNFSF10 Long Name: TNF-related Apoptosis-inducing Ligand Aliases: CD253; TNFSF10 Entrez Gene IDs: 8743 (Human); 22035 (Mouse) Background: TRAIL/TNFSF10 TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. Among TNF superfamily members, TRAIL is the most homologous to Fas Ligand, sharing 28% amino acid sequence identity in their extracellular domains. Human TRAIL shares 65% amino acid sequence identity with mouse TRAIL and is active on mouse cells.