货号：07-1522

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-eIF3A Antibody | 07-1522 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~167 kDa observed. An uncharacterized band may be observed at a molecular weight of ~97 kDa in some cell lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to eIF3A. View All» Background Information: eIF3a is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which coordinates a myriad of protein-protein interactions that mediates the translation initiation process in eukaryotes. In particular, the eIF-3 complex is known to stimulate the recruitment of eIF-1, eIF-1a, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex is known to recruit mRNA to the 43SPIC complex, which then initiates scanning of mRNA for the AUG start codon. In addition, the eIF-3 complex is required for disassembly and recycling of post-termination ribosomal complexes and prevents the premature joining of the 40S and 60S ribosomal subunits prior to initiation. View All» Species Reactivity:

• Human

• Chimpanzee

• Horse

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Chimpanzee, Equine, Mouse, and Rat based on 100% sequence homology. View All» Control: HEK293T cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293T cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected eIF3A in HEK293T cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14152 View All» Entrez Gene Number: NP_003741 View All» Gene Symbol:
  • EIF3A

  • EIF3S10

  • KIAA0139
    View All» Alternate Names: Eukaryotic translation initiation factor 3 subunit A View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.SUBUNIT STRUCTURE: Interacts with EIF4G1. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.SUBCELLULAR LOCATION: Cytoplasm. View All» Product Name: Anti-eIF3A View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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