金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P09619 N-terminal Sequence Analysis:Leu33 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:84 kDa (monomer) SDS-PAGE:150 kDa, reducing conditions Activity:Measured by its ability to inhibit the biological activity of PDGF-BB using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749.The ED₅₀ for this effect is typically 1 - 3 µg/mL in the presence of 4 ng/mL rhPDGF-BB. Molecule Information: PDGF R beta Long Name: Platelet-derived Growth Factor Receptor beta Aliases: CD140b; PDGFRB Entrez Gene IDs: 5159 (Human); 18596 (Mouse); 24629 (Rat) Background: PDGF R beta View PDGF R beta IHC images. PDGF isoforms exert their cellular effects by binding to the structurally similar receptor tyrosine kinases (RTK), PDGF R alpha (CD140a) and PDGF R beta (CD140b). PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of RTK which are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization leading to signal transduction. The expression of PDGF alpha and beta receptors is independently regulated in various cell types.