货号：07-1526

品牌：Merck Millipore

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目录价：￥4013.00

市场价格：￥3411.05

会员价格：￥3210.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-BRD2 (Ser37) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes BRD2 phosphorylated at Ser37. View All» Molecular Weight: ~110 kDa observed. An uncharacterized band at ~90 kDa may be observed in some lysates. View All» Epitope: Phosphorylated Ser37 View All» Immunogen: Linear peptide corresponding to human BRD2 phosphorylated at Ser37. View All» Modifications: Phosphorylation View All» Background Information: Bromodomain-containing protein 2 (BRD2) is a member of the BET subfamily of bromodomain proteins. These proteins contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal domain. Studies have shown BRD2 to be associated with several regulators of transcription (eg. TFIID and Swi/Snf complexes) in addition to its involvement in guiding cell cycle gene expression through its binding to multiple E2F. BRD2 is hypothesized to function in mammalian development by regulating chromatin structure and transcription. Consistent with this hypothesis, studies have shown BRD2 to bind histone H4 via acetylated Lys12. BRD2 mutants have been associated with increased susceptibility to juvenile myoclonic epilepsy. View All» Species Reactivity:

• Human

• Mouse

• Monkey

• Rat

• Bovine

• Pig

• Xenopus
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Monkey. Predicted to react with Rat, Bovine, Porcine, Xenopus, and Zebra Fish based on 100% sequence homology. View All» Control: PMA untreated and treated NIH/3T3 cell lysates View All» Quality Assurance: Evaluated by Western Blot in PMA untreated and treated NIH/3T3 cell lysates.Western Blot Analysis: 2 µg/mL of this antibody detected BRD2 on 10 µg of PMA untreated and treated NIH/3T3 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P25440 View All» Entrez Gene Number: NP_005095 View All» Gene Symbol:
  • BRD2

  • RING3
    View All» Alternate Names:
    • Bromodomain-containing protein 2

    • O27.1.1

    • Really interesting new gene 3 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]. View All» UniProt Summary: FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity).SUBUNIT STRUCTURE: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'. SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.SEQUENCE SIMILARITIES: Contains 2 bromo domains.Contains 1 ET domain.SEQUENCE CAUTION: The sequence AAA68890.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-phospho-BRD2 (Ser37) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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