货号：07-1535

品牌：Merck Millipore

规格：100Ug

目录价：￥5141.00

市场价格：￥4369.85

会员价格：￥4112.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD1B (N-terminus) Antibody | 07-1535 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes human JMJD1B. View All» Molecular Weight: ~190 kDa View All» Epitope: N-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to the N-terminal region of human JMJD1B. View All» Background Information: Methylation of histones plays a critical role in regulating chromatin structure and transcription. The JMJD1 (Jumonji domain-containing protein 1) family, also known as JHDM2 (JmjC domain-containing histone demethylation protein 2) family, contains four members: hairless (HR), JMJD1A/JHDM2A, JMJD1B/JHDM2B, and JMJD1C/JHDM2C. JMJD1B has been shown to specifically demethylate mono-methyl and di-methyl histone H3 on lysine9. H3Lys9 methylation is a highly studied histone mark that represses gene expression and implicates JMJD1B as a key regulator of heterochromatin assembly. Deletions in the gene encoding JMJD1B are frequently associated with myeloid leukemias and myelodysplasias, suggesting JMJD1B also may act as a tumor suppressor. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, mouse. Not tested in other species. View All» Application Notes: Immunocytochemistry:HeLa and NIH/3T3 cells incubated with anti-JMJD1B (N-terminus) stained positively on nuclei.ELISA: This antibody was reported by an outside laboratory to be suitable for ELISA. View All» Control: Raji nuclear extract View All» Quality Assurance: Western Blot Analysis:1:250 dilution of this antibody detected JMJD1B on 10 µg of Raji nuclear extract. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q7LBC6 View All» Entrez Gene Number: NP_057688.2 View All» Gene Symbol:
  • 5qNCA

  • C5orf7

  • EC 1.14.11.-

  • JHDM2B

  • KDM3B

  • KIAA1082
    View All» Alternate Names:
    • JMJD

    • Jumonji domain-containing protein 1B

    • Nuclear protein 5qNCA

    • chromosome 5 open reading frame 7

    • jumonji domain containing 1B
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • ELISA
        View All» UniProt Summary: FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. COFACTOR: Binds 1 Fe(2+) ion per subunit By similarity.SUBCELLULAR LOCATION: NucleusBy similarity. TISSUE SPECIFICTY: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity.MISCELLANEOUS: Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain. View All» Product Name: Anti-JMJD1B (N-terminus) Antibody (07-1535) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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