货号：07-1545

品牌：Merck Millipore

规格：EA

目录价：￥4410.00

市场价格：￥3748.50

会员价格：￥3528.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GCN5L2 (N-terminus) Antibody | 07-1545 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes human GCN5L2. View All» Molecular Weight: ~93 kDa View All» Epitope: N-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to the N-terminal region of human GCN5L2. View All» Background Information: Acetylation of histones is a specific epigenetic mark for transcription activation. GCN5L2 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Human, mouse. Not tested in other species. View All» Application Notes: Western Blot Analysis:This antibody was used by an outside laboratory to detect GCN5L2 in mouse liver lysate (1:60 dilution).ELISA: This antibody was reported by an outside laboratory to be suitable for ELISA (1:1000 dilution). View All» Control: A431 or HeLa cells View All» Quality Assurance: Evaluated by Immunocytochemistry on A431 or HeLa cells.Immunocytochemistry:Confocal immunofluorescence analysis of A431 and HeLa cells using anti-GC5L2 (N-terminus) (Red). Actin filaments have been labeled with Alexa Fluor 488-Phalloidin (Green). View All» Purification Method: Protein G chromatography View All» Presentation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q92830 View All» Entrez Gene Number: NP_066564.2 View All» Gene Symbol:
  • EC 2.3.1.48

  • GCN5

  • GCN5L2

  • HGCN5

  • MGC102791

  • PCAF-b

  • STAF97

  • hGCN5

  • hGCN5
    View All» Alternate Names:
    • GCN5 (general control of amino-acid synthesis, yeast,homolog)-like 2

    • GCN5 general control of amino-acid synthesis 5-like 2

    • GCN5 general control of amino-acid synthesis 5-like 2(yeast)

    • General control of amino acid synthesis, yeast,homolog-like 2

    • Histone acetyltransferase GCN5

    • K(lysine) acetyltransferase 2A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting

      • ELISA
        View All» UniProt Summary: FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.Catalytic activity Acetyl-CoA + histone = CoA + acetylhistone.SUBUNIT STRUCTURE: Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TAF3, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitinylation composed of ATXN7L3, ENY2 and USP22. Interacts with and acetylates HIV-1 Tat. Ref.8 Ref.9 Ref.10 Ref.11SUBCELLULAR LOCATION: Nucleus. Ref.6TISSUE SPECIFICITY: Expressed in all tissues tested, with most abundant expression in ovary.SIMILARITY: Belongs to the GCN5 family.Contains 1 bromo domain.Contains 1 N-acetyltransferase domain. View All» Product Name: Anti-GCN5L2 (N-terminus) Antibody (07-1545) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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