金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Met1-Asn932 Accession #:P08069 N-terminal Sequence Analysis:Glu31 andAsp741 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:102.9kDa (single chain); 81.0 kDa ( alpha chain)&21.9 kDa ( beta chain) SDS-PAGE:160 kDa, 125 kDa, 50 kDa& 40kDa, reducing conditions Activity:Measured by its ability to bind human IGF-I in a functional ELISA. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IGF-I R Long Name: Insulin-like Growth Factor I Receptor Aliases: CD221; IGF1R Entrez Gene IDs: 3480 (Human) Background: IGF Receptors

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.