货号：07-1584

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-dimethyl Histone H4 (Lys20) Antibody | 07-1584 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes histone H4 acetylated on Lys20, Mr ~10 kDa. View All» Molecular Weight: ~10 kDa View All» Immunogen: KLH-conjugated, synthetic peptide containing the sequence (AKRHR[dimethyl-K]VLRD-C), corresponding to the sequence surrounding acetylated lysine 20 of human histone H4. View All» Modifications: Methylation View All» Background Information: Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). In mammals, H4K20 methylation is one of the most common chromatin modifications and it has been implicated in various biological processes, including heterochromatin formation, telomere function, imprinting, X inactivation, DNA damage repair and cancer progression. H4K20me2 is the most abundant histone modification with more that 80% of all histone H4 molecules carrying this mark. The Suv4-20h enzymes are the two major histone methyltransferases to induce H4K20me2 and me3 states. View All» Species Reactivity: Human View All» Species Reactivity Note: Broad species cross-reactivity expected due to sequence homology View All» Quality Assurance: Routinely evaluated by immunoblot on HeLa nuclear extract View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: P62805 View All» Entrez Gene Number: NM_175054 View All» Alternate Names:

• H4K20me2

• Histone H4 (di methyl K20)
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. View All» UniProt Summary: FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. INTERACTION:Q13547:HDAC1; NbExp=1; IntAct=EBI-302023, EBI-301834;P56524:HDAC4; NbExp=1; IntAct=EBI-302023, EBI-308629;Q9UQL6:HDAC5; NbExp=1; IntAct=EBI-302023, EBI-715576;Q9UBN7:HDAC6; NbExp=1; IntAct=EBI-302023, EBI-301697;Q9Y468:L3MBTL; NbExp=2; IntAct=EBI-302023, EBI-1265089;Q9SU94:PRMT1.1 (xeno); NbExp=1; IntAct=EBI-302023, EBI-1382731;O82210:PRMT1.2 (xeno); NbExp=1; IntAct=EBI-302023, EBI-1382526;Q9NQR1:SETD8; NbExp=4; IntAct=EBI-302023, EBI-1268946;SUBCELLULAR LOCATION: Nucleus. PTM: Acetylation at Lys-6, Lys-9, Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin. PTM: Citrullination at Arg-4 by PADI4 impairs methylation. PTM: Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6. PTM: Monomethylated, dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing. PTM: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. PTM: Sumoylated, which is associated with transcriptional repression. SIMILARITY: Belongs to the histone H4 family. View All» Brand Family: Upstate View All» Product Name: Anti-dimethyl Histone H4 (Lys20) Antibody View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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