货号：07-1602

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRAK4 Antibody, C-terminus | 07-1602 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IRAK4 at the C-terminus. View All» Molecular Weight: ~51 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK4. View All» Background Information: IRAK4, also known as interleukin-1 receptor associated kinase 4, and belongs to the tyrosine kinase related (TKL) family, which is important for innate immune responses. IRAK4 is the closest human homolog to Pelle and combines signals from the receptor complex in the plasma membrane with the cytosol. IRAK4 phosphorylates IRAK1 which is then recruited to the IL-1 receptor complex, resulting in mRNA stabilization. NF-kappa B is activated by the kinase activity of IRAK4 through the TLR and TCR pathways. Mutations result in deficiency of IRAK4 which leads to recurring invasive pneumoccocal disease, extracellular pyogenic bacterial and fungal infections. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. View All» Control: Jurkat lysate View All» Quality Assurance: Evaluated by western blot on jurkat lysate.Western Blot Analysis: A 1:25-1:500 dilution of this antibody detected IRAK4 on jurkat lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9NWZ3 View All» Entrez Gene Number: NP_001107654.1 View All» Gene Symbol:

• IRAK-4

• IPD1

• NY-REN-64

• REN64

• EC 2.7.11.1
  View All» Alternate Names:
  • interleukin-1 receptor-associated kinase 4

  • interleukin-1 receptor associated kinase 4

  • NY-REN-64 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq] View All» UniProt Summary: Function: Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1. Catalytic activity: ATP + a protein = ADP + a phosphoprotein.Cofactor Magnesium.Subunit structure: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1. Involvement in disease: Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.Contains 1 death domain.Contains 1 protein kinase domain. View All» Product Name: Anti-IRAK4, C-terminus View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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