金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ser160-Ser391 & Lys178-Ser391 Accession #:Q92838 N-terminal Sequence Analysis:Ser160 & Lys178 Structure:Homotrimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:24.1 kDa & 22.2 kDa (monomers) SDS-PAGE:30-40 kDa, reducing conditions Activity:Measured by its ability to compete with biotinylated human EDA-A1 for binding to immobilized rhEDAR/Fc Chimera. Molecule Information: EDA-A1/Ectodysplasin A1 Entrez Gene IDs: 1896 (Human); 13607 (Mouse) Background: Ectodysplasin-A1 (EDA-A1) Ectodysplasin-A1 (EDA-A1) is a type II transmembrane protein belonging to the TNF superfamily. It is one of multiple isoforms encoded by the EDA gene. Human EDA-A1 is a 391 amino acid protein with a predicted molecular mass of 41 kDa. Mouse and rat EDA-A1 share 94% amino acid sequence identity with the human protein. EDA-A1 is expressed by keratinocytes, hair follicles, and sweat glands, where it can be localized to the cell surface or cleaved into a soluble form by Furin. EDA-A1 forms a homotrimeric protein that binds to EDAR and activates NF-kappa B signaling. Mutations in EDA are associated with a group of developmental disorders identified as ectodermal dysplasia type 1.