货号：07-1673

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SOX1 Antibody | 07-1673 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SOX1. View All» Immunogen: Synthetic peptide corresponding to SOX1. View All» Background Information: Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Human. Predicted to react with mouse based on sequence homology. View All» Quality Assurance: Evaluated by immunohistochemistry on human epidermis.Immunohistochemistry(paraffin): A 1:300 dilution of this antibody was used to detect SOX1 in human epidermis. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt.To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10 μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses. View All» UniProt Number: O00570 View All» Entrez Gene Number: NM_009233 View All» Gene Symbol:
  • SOX1

  • SRY
    View All» Alternate Names:
    • SRY (sex determining region Y)-box 1

    • SRY-related HMG-box gene 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» UniProt Summary: FUNCTION: Transcriptional activator By similarity.SUBCELLULAR LOCATION: NucleusProbable. TISSUE SPECIFICITY: Mainly in the developing central nervous system.SIMILARITY: Contains 1 HMG box DNA-binding domain. View All» Product Name: Anti-SOX1 Antibody | 07-1673 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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