货号：07-1708

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FOXH1 Antibody | 07-1708 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FOXH1. View All» Molecular Weight: 38 kDa View All» Immunogen: Synthetic to peptide corresponding to FOXH1. View All» Background Information: Forkhead box H1 (FOXH1) is a member of the HNF–3FKH family of transcriptional activators. FOXH1 is a winged helix with two loops on the C-terminal side expressed in all human tissue. FOXH1 is an embryonic transcription regulator and is an essential transcriptional co-activator that binds with SMAD2 to activate activin, and therefore induce the gooseciod (GSC) promoter. After FOXH1 binds to SMAD4, activin response element is activated and TGF-β is stimulated. FOXH1 also interacts with NKX2-5 to form an essential component of anterior heart field development. FOXH1 is associated with complex brain malfunctions due to incomplete cleavage of the prosencephalon, and in developmental delays resulting in facial abnormalities such as cyclopia and severe cleft lip or palate. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Human. Predicted to react with mouse based on sequence homology. View All» Control: NIH/3T3, HeLa, and A431 cells. View All» Quality Assurance: Evaluated by immunocytochemistry on NIH/3T3, HeLa, and A431 cells.Immunocytochemistry: 1:500 dilution of this antibody was used to detect FOXH1 in NIH/3T3, HeLa and A431 cells. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt.To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 4-25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses. View All» UniProt Number: O75593 View All» Entrez Gene Number: NM_007989 View All» Gene Symbol:
  • FAST-1

  • FAST1

  • FAST2

  • Fast-1

  • Fast-2

  • hFAST-1
    View All» Alternate Names:
    • Forkhead activin signal transducer 1

    • Forkhead activin signal transducer 2

    • TGF-beta/activin signal transducer

    • forkhead activin signal transducer-1

    • forkhead box H1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» UniProt Summary: FUNCTION:Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). Ref.1SUBUNIT: Interacts with the MH2 domains of SMAD2 and SMAD3. Ref.1SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. Ref.1DOMAIN:The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex By similarity.Sequence similarities Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-FOXH1 Antibody (07-1708) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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