货号：07-172

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FHIT (fragile histidine triad) Antibody | 07-172 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: FHIT View All» Molecular Weight: 17kDa View All» Immunogen: Full-length whole human FHIT protein View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from COS-1 cells transiently transfected with FHIT cDNA (wild type) in pUSEamp (21-186) View All» Purification Method: Protein A chromatography View All» Presentation: 75mM Tris base, 75mM glycine, pH 7.0, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P49789 View All» Entrez Gene Number: NM_002012 View All» Gene Symbol:
  • FHIT

  • Dinucleosidetriphosphatase

  • AP3Aase

  • bis(5'-adenosyl)-triphosphatase

  • Bis

  • FRA3B

  • dinucleosidetriphosphatase

  • 5'-adenosyltriphosphatase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. View All» UniProt Summary: FUNCTION: SwissProt: P49789 # Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.COFACTOR: Divalent cations. Magnesium, but manganese and to a lesser extent calcium or cobalt can be substituted; but not zinc, cadmium or nickel.SIZE: 147 amino acids; 16858 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.DISEASE: SwissProt: P49789 # A chromosomal aberration involving FHIT is observed in early onset bilateral and multifocal clear cell renal carcinoma [MIM:144700]. Translocation t(3;8) (3p14.2). & Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B.SIMILARITY: SwissProt: P49789 ## Contains 1 HIT domain. View All» Brand Family: Upstate View All» Product Name: Anti-FHIT (fragile histidine triad) Antibody | 07-172 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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