货号：07-1801

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-G3BP1 Antibody | 07-1801 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects G3BP1 at its C-terminal region. View All» Molecular Weight: 68 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to C-terminal region of human G3BP1. View All» Background Information: G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Human and Mouse. Not tested on other species. Rat expected to react as immunogen is 100% homologous. View All» Control: HeLa cell lysates. View All» Quality Assurance: Evaluated by western blot on HeLa cell lysates. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect G3BP1 in HeLa, 293T and S10 cell lysates. View All» Presentation: Rabbit polyclonal serum with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q13884 View All» Entrez Gene Number: NP_005745 View All» Gene Symbol:
  • EC 3.6.1

  • G3BP

  • G3BP-1

  • HDH-VIII
    View All» Alternate Names:
    • ATP-dependent DNA helicase VIII

    • GAP SH3 domain-binding protein 1

    • GAP binding protein

    • GTPase activating protein (SH3 domain) binding protein 1

    • Ras-GTPase-activating protein SH3-domain-binding protein

    • RasGAP-associated endoribonuclease G3BP
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.SUBUNIT STRUCTURE: Monomer and homodimer Probable. Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A By similarity. Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.SUBCELLULAR LOCATION: Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic sideBy similarity. Cell junctionBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions By similarity.TISSUE SPECIFICITY:Ubiquitous. Ref.1DOMAIN: The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.The SU domain binds calmodulin in a calcium-dependent manner By similarity.PTM: Phosphorylated by CaM-kinase II By similarity.SIMILARITY:Belongs to the syntrophin family.Contains 1 PDZ (DHR) domain.Contains 2 PH domains.Contains 1 SU (syntrophin unique) domain. View All» Product Name: Anti-G3BP1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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