货号：07-1802

品牌：Merck Millipore

规格：100UL

目录价：￥4746.00

市场价格：￥4034.10

会员价格：￥3796.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TAF3 Antibody | 07-1802 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~180 kDa observed. View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human TAF3. View All» Background Information: TAF3 is a subunit of TFIID that was initially identified through its interaction with a developmentally regulated transcription factor Bric a brac 1 (bab1), which is implicated in pattern formation and tissue morphogenesis in Drosophila. TFIID is a general or basal transcription factor that regulates initiation by allowing RNA polymerase II to recognize a core promotor. TAF3-TBPL2 complexes are found in myoblasts; however, upon differentiation into myotubes, they are replaced by TRF3-TAF3 complexes. Further research is still required to elucidate the roles and the development of the former to the latter complex. View All» Species Reactivity:

• Mouse

• Rhesus Macaque

• Guinea Pig
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human, Rhesus Macaque and Guinea Pig based on sequence homology. View All» Application Notes: Chromatin Immunoprecipitation: A representative lot immunoprecipitated TAF3 using chromatin from transfected cells grown under conditions that favor expression from the MyoD:EGFP transgene promoter over expression from the endogenous MyoD promoter. View All» Control: C2C12 cell lysate. View All» Quality Assurance: Evaluated by Immunoprecipitation in C2C12 cell lysate.Immunoprecipitation Analysis: A 1:1,000 dilution of this antibody detected TAF3 in 500 µg of C2C12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q5VWG9 View All» Entrez Gene Number: NP_114129.1 View All» Gene Symbol: TAF3 View All» Alternate Names:
  • Transcription initiation factor TFIID subunit 3

  • 140 kDa TATA box-binding protein-associated factor

  • TBP-associated factor 3Transcription initiation factor TFIID 140 kDa subunit

  • TAF(II)140

  • TAF140

  • TAF140

  • TAFII140
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunoprecipitation View All» Entrez Gene Summary: The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors. View All» UniProt Summary: FUNCTION: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.SUBUNIT STRUCTURE: Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.SUBCELLULAR LOCATION: Nucleus. View All» Product Name: Anti-TAF3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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