货号：07-1818

品牌：Merck Millipore

规格：EA

目录价：￥3348.00

市场价格：￥2845.80

会员价格：￥2678.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SKAR Antibody | 07-1818 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects SKAR. View All» Molecular Weight: ~46-50 kDa.Non-specific bands may be detected at ~40 kDa and ~200 kDa. View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to SKAR. View All» Background Information: The mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) signaling pathways promote cell growth and cell cycle progression in response to nutritional, energy, and mitogenic cues. In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstream of mTOR and PI3K, suggesting that translational control through the phosphorylation of S6 regulates cell growth. SKAR is a specific binding partner and substrate of S6K1 but not S6K2. Serines 383 and 385 of human SKAR are insulin-stimulated and rapamycin-sensitive S6K1 phosphorylation sites. SKAR is nuclear protein with homology to the Aly/REF family of RNA binding proteins, which has been proposed to couple transcription with pre-mRNA splicing and mRNA export (Richardson, C.J., 2004). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Tested on human, mouse and rat. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by western blot on HeLa cell lysate.Western Blot Analysis: 1:1000 dilution of this antibody detected SKAR in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» Entrez Gene Number: NP_115687.2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. View All» Product Name: Anti-SKAR View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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