货号：07-1840

品牌：Merck Millipore

规格：EA

目录价：￥4164.00

市场价格：￥3539.40

会员价格：￥3331.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Acinus (Ser422) Antibody | 07-1840 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes Acinus phosphorylated at Ser422. View All» Molecular Weight: The molecular weight of phospho-Acinus-L is ~ 220 kDa, phospho-Acinus-S' and S are ~ 100 kDa. The caspase degraded form is approximately 58 kDa. View All» Epitope: Phosphorylated Ser422 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Acinus phosphorylated at Ser422. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: Acinus (Apoptotic Chromatin condensation Inducer in the Nucleus) is a ubiquitously expressed nuclear factor essential for apoptotic chromatin condensation. The ~220 kDa acinus protein is cleaved by caspase-3 and an additional unidentified protease. This protelytic cleavage releases a 17 kDa fragment to induce chromatin condensation. Acinus is expressed in three isoforms, AcinusL, AcinusS, and AcinusS' with the two shorter isoforms corresponding to the C-terminal region of the longer form. View All» Species Reactivity:

• Rat

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology. View All» Control: NGF treated and untreated PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NGF treated and untreated PC12 cell lysate.Western Blot Analysis:1:1,000 dilution of this antibody detected Acinus on 10 µg of NGF treated and untreated PC12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal containing serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9UKV3 View All» Entrez Gene Number: NP_055792 View All» Gene Symbol:
  • ACIN1

  • ACINUS

  • CAN

  • Acinus
    View All» Alternate Names:
    • apoptotic chromatin condensation inducer 1

    • apoptotic chromatin condensation inducer in the nucleus

    • functional spliceosome-associated protein 152
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Induces apoptotic chromatin condensation after activation by CASP3.SIZE: 1341 amino acids; 151888 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous.PTM: Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.SIMILARITY: Contains 1 SAP domain. View All» Product Name: Anti-phospho-Acinus (Ser422) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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