货号：07-206

品牌：Merck Millipore

规格：

目录价：￥4750.00

市场价格：￥4037.50

会员价格：￥3800.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-SHC (Tyr317) Antibody | 07-206 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: phosphorylated SHC protein isoforms View All» Molecular Weight: 46, 52, and 67kDa isoforms View All» Immunogen: peptide (FDDPS[pY]VN-C) corresponding to amino acids 312-319 of human p52 SHC, containing a C-terminal cysteine. This motif is the Grb2 binding site. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HFF cells stimulated with EGF View All» Purification Method: Immunoaffinity chromatography View All» Presentation: 0.2M Tris-glycine, 150mM NaCl, 0.05% sodium azide and 5mg/ml BSA before the addition of glycerol to 30% View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: P29353 View All» Entrez Gene Number: NM_003029 View All» Gene Symbol:
  • SHC1

  • FLJ26504

  • SHC

  • p66SHC

  • SHCA

  • p52SHC

  • p66
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P29353 # Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity).SIZE: 583 amino acids; 62852 Da SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine- dependent manner. Interacts with the NPXY motif of tyrosine- phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2.SUBCELLULAR LOCATION: Cytoplasm. & Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.TISSUE SPECIFICITY: Widely expressed. Expressed in neural stem cells but absent in mature neurons.DOMAIN: SwissProt: P29353 In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).PTM: Phosphorylated by activated epidermal growth factor receptor. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity).SIMILARITY: Contains 1 PID domain. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-SHC (Tyr317) Antibody | 07-206 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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