货号：07-207

品牌：Merck Millipore

规格：

目录价：￥4037.00

市场价格：￥3431.45

会员价格：￥3229.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Numb (pan-isoform) Antibody | 07-207 View All» Replaces: AB9572 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes all 4 Numb isoforms View All» Molecular Weight: Mr 66/65 and 71/72kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding the C-terminus common to all four isoforms of mouse Numb (C-TNPFSSDLQKTFEIEL) containing an N-terminal cysteine View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on modified RIPA lysates from A431 cells View All» Purification Method: Protein A purfied View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P49757 View All» Entrez Gene Number: NM_010949 View All» Gene Symbol:
  • NUMB

  • S171

  • h-Numb
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P49757 # Implicated in the control of cell fate decisions during development.SIZE: 651 amino acids; 70804 Da SUBUNIT: Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.SIMILARITY: SwissProt: P49757 ## Contains 1 PID domain. View All» Brand Family: Upstate View All» Product Name: Anti-Numb (pan-isoform) Antibody | 07-207 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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