货号：07-226

品牌：Merck Millipore

规格：

目录价：￥5141.00

市场价格：￥4369.85

会员价格：￥4112.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TrkC Antibody | 07-226 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Molecular Weight: 145kDa View All» Immunogen: Extracellular domain of rat TrkC receptor, corresponding to amino acid residues 1-429 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Purification Method: Protein G chromatography View All» UniProt Number: Q16288 View All» Entrez Gene Number: NM_019248 View All» Gene Symbol:
  • NTRK3

  • TRKC

  • Trk-C

  • gp145(trkC)

  • GP145-TrkC
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. View All» UniProt Summary: FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.SIZE: 839 amino acids; 94428 Da SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.PTM: Ligand-mediated auto-phosphorylation.SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-TrkC Antibody | 07-226 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Goat View All»
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