货号：07-228

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TACC2 Antibody | 07-228 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Molecular Weight: Observed molecular weight, 73 kDa. Note this protein can be highly modified and several isoforms exist. View All» Epitope: Mature chain View All» Immunogen: KLH-conjugated linear peptide corresponding to the mature chain of mouse TACC2. View All» Background Information: TACC2, also known as transforming acidic coiled-coil-containing protein 2, belongs to the transforming acidic coiled-coil-containing (TACC) protein family. This group of proteins is defined by its highly conserved coiled-coil domain. This domain is necessary for the assignment of the centrosome-spindle apparatus during cell cycling. There are three proteins belonging to the TACC family; TACC1, TACC2, and TACC3. TACC2 has been reported as playing a necessary role in cultured cell microtubule stabilization. It has also been shown that the binding of TACC2 by T antigen can cause chromosomal instability and mitotic defects (Tei, 2009). Research into the over expression of TACC2 strongly suggests a potential function as a tumor suppressor (Tei, 2009). View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology. View All» Control: Mouse testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse testis tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected TACC2 on 10 µg of mouse testis tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JJG0 View All» Entrez Gene Number: NP_996738 View All» Gene Symbol:
  • TACC2

  • AZU-1

  • ECTACC
    View All» Alternate Names: transforming, acidic coiled-coil containing protein 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity). SUBUNIT STRUCTURE: Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF By similarity. Interacts with CCDC100/CEP120. SUBCELLULAR LOCATION: Cytoplasm By similarity. Nucleus By similarity. Cytoplasm › cytoskeleton › centrosome (By similarity).TISSUE SPECIFICTY: Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level. PTM: Phosphorylated; which is required for localization in centrosome (By similarity). DISRUPTION PHENOTYPE: Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction. SEQUENCE SIMILARITIES: Belongs to the TACC family.Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain. View All» Brand Family: Upstate View All» Product Name: Anti-TACC2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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