货号：07-249

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMURF2 Antibody | 07-249 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SMURF 2 View All» Molecular Weight: 86kDa View All» Immunogen: peptide corresponding to amino acids 161-174 (C-DGWEERRTASGRIQ) of human SMURF 2 View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HepG2 cells View All» Purification Method: Serum View All» Presentation: antiserum containing 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q9HAU4 View All» Entrez Gene Number: NM_022739 View All» Gene Symbol:

• SMURF2

• DKFZp686F0270

• MGC138150

• hSMURF2
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q9HAU4 # E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.SIZE: 748 amino acids; 86196 Da SUBUNIT: Interacts with SMAD1, SMAD2, SMAD3, SMAD6 and SMAD7 but not SMAD4.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic in the presence of SMAD7.TISSUE SPECIFICITY: Widely expressed.DOMAIN:SwissProt: Q9HAU4 The second and third WW domains are responsible for interaction with R-SMAD (SMAD1, SMAD2 and SMAD3).SIMILARITY: Contains 1 C2 domain. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 3 WW domains. View All» Brand Family: Upstate View All» Product Name: Anti-SMURF2 Antibody | 07-249 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
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