金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ala26-Pro653 (Ala26Thr), with a C-terminal 10-His tag Accession #:AAA81589 N-terminal Sequence Analysis:Thr26 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:71 kDa SDS-PAGE:83 kDa, reducing conditions Activity:Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl alpha -L-iduronide. The specific activity is >7,500 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Sodium Acetate, NaCl and Glycerol.See Certificate of Analysis for details. Molecule Information: alpha-L-Iduronidase/IDUA Aliases: IDA; IDUA; MPS1 Entrez Gene IDs: 3425 (Human); 15932 (Mouse); 360904 (Rat) Background: alpha-L-Iduronidase/IDUA alpha-L-Iduronidase, encoded by the IDUA gene, is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non-reducing terminal a-L-iduronic acid residues in GAGs, including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue, and organ damage.