货号：07-293

品牌：Merck Millipore

规格：

目录价：￥4247.00

市场价格：￥3609.95

会员价格：￥3397.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PICK1 Antibody | 07-293 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: PICK1 View All» Molecular Weight: 55kDa View All» Immunogen: His-tagged fusion protein corresponding to residues 317-416 of mouse PICK1 View All» Isotype: IgG View All» Species Reactivity:

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from rat brain microsomal preparation View All» Purification Method: Immunoaffinity chromatography View All» Presentation: 50mM Glycine, pH 7.4, 0.2M Tris, 0.15M NaCl, 0.1mM EDTA, 5mg/ml BSA, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: Q9NRD5 View All» Entrez Gene Number: NM_012407 View All» Gene Symbol:
  • PICK1

  • OTTHUMP00000028509

  • MGC15204

  • dJ1039K5

  • PRKCABP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q9NRD5 # Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3-ACCN2 heteromeric cation channel.SIZE: 415 amino acids; 46600 Da SUBUNIT: Monomer and homodimer. Interacts presynaptically with the monoamine transporters SLC6A2 and SLC6A3; with the channel proteins ACCN1 and ACCN2; with the GTP-binding proteins ARF1 and ARF3. Interacts with PRKCA; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; and with ERBB2. Interacts with BTG2; with the glutamate receptors GRIA2, GRIA3, the isoform A of GRM4, GRM7 and GRM8; and with NAPA and NAPB. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with UNC5A (By similarity). Interacts with CXADR. Interacts through its PDZ domain with the C-terminal tail of PRLHR.SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses.TISSUE SPECIFICITY: Ubiquitous.PTM: Phosphorylated (By similarity).SIMILARITY: SwissProt: Q9NRD5 ## Contains 1 AH domain. & Contains 1 PDZ (DHR) domain. View All» Brand Family: Upstate View All» Product Name: Anti-PICK1 Antibody | 07-293 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Target / Localization: Postsynaptic View All» Format: Affinity Purified View All» Host: Rabbit View All»
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