金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:Q14943 N-terminal Sequence Analysis:His22 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:61.9 kDa (monomer) SDS-PAGE:75-90 kDa, reducing conditions Activity:Measured by its ability to bind MDA‑MB‑231 human breast cancer cells in a flow cytometry assay.A 200 - 500 fold increase in fluorescence intensity can be observed when MDA-MB-231 cells are stained with 3 µg/mL rhKIR3DS1/Fc Chimera and goat anti-human Fc-PE as compared to cells stained with goat anti-human Fc-PE. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: KIR3DS1/CD158e2 Long Name: Killer Cell Immunoglobulin-like Receptor, Three Domains, Long Cytoplasmic Tail, 1 Aliases: CD158e2; KIR-G1; nkat10 Entrez Gene IDs: 3813 (Human) Background: KIR Family The KIR family is composed of at least 15 members expressed by natural killer (NK) cells and a subset of T cells in primates only. KIR proteins are named based on the number of extracellular Ig-like domains (KIR2D or KIR3D) and for whether the cytoplasmic domain is long (L), or short (S). Inhibitory KIR proteins possess long cytoplasmic tails with ITIM (inhibitory) domains, and several of these molecules bind HLA Class I molecules or target cells. Activating KIR proteins have short tails; their targets are less well-known. KIR2DL4 (CD158d) is unique in that it shows both inhibitory and activating characteristics.