金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Gly2-Lys324, with a C-terminal 6-His tag Accession #:NP_808820 N-terminal Sequence Analysis:Gly2 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:37 kDa SDS-PAGE:41 kDa, reducing conditions Activity:Measured by its ability to dephosphorylate the peptide substrate, DLDVPIPGRFDRRVS(PO₃)VAAE(Catalog# ES012).The specific activityis >400 nmol/min/mg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in HEPES, NaCl, MnCl₂ and DTT.See Certificate of Analysis for details. Molecule Information: PP2C alpha/PPM1A Long Name: Protein Phosphatase 2C alpha Aliases: MMPa-2; MPPa-1; Pp2c1; PPM1A Entrez Gene IDs: 5494 (Human); 19042 (Mouse); 24666 (Rat) Background: PP2C alpha Protein phosphatase 2C alpha, also called PP2C alpha, Protein Phosphatase, Magnesium-dependent type 1A, and PPM1A, dephosphorylates proteins with some preference for phospho-threonine over phospho-serine residues. It is insensitive to the PP1 and PP2a inhibitors such as okadaic acid, but has an absolute requirement for either magnesium or manganese ions and can be activated by unsaturated fatty acids such as arachidonic and oleic acids. Overexpression of PP2C alpha causes G2/M cell cycle arrest and apoptosis that has been associated with the activation of p53. Dephosphorylation of proteins in the nucleus by PP2C alpha is suspected to play a role in terminating or reducing the sensitivity of the responses to SMADS and stress-activated proteins such as p38 and JNK.