货号：07-334

品牌：Merck Millipore

规格：

目录价：￥3545.00

市场价格：￥3013.25

会员价格：￥2836.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PP2A Antibody, B' subunit | 07-334 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: PP2A B' subunit, all isoforms View All» Molecular Weight: 55kDa View All» Immunogen: peptide corresponding to amino acids 194-209 (ELFDSEDPRERDFLKT) of human B56 α isoform View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rabbit
  View All» Quality Assurance: routinely evaluated by immunoblot on Jurkat cell lysates View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q00005 View All» Entrez Gene Number: NM_004576 View All» Gene Symbol:
  • PPP2R2B

  • PR2AB-BETA

  • PP2A-B55beta

  • PP2A-PR55B

  • SCA12

  • PR52B

  • PR2APR55-BETA

  • PR2AB55-BETA

  • MGC24888

  • PR55-BETA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12. View All» UniProt Summary: FUNCTION: SwissProt: Q00005 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.SIZE: 443 amino acids; 51710 Da SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.TISSUE SPECIFICITY: Brain.DISEASE: SwissProt: Q00005 # Defects in PPP2R2B are the cause of spinocerebellar ataxia 12 (SCA12) [MIM:604326]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The molecular defect in SCA12 is the expansion of a CAG repeat in the 5'-UTR of the gene.SIMILARITY: SwissProt: Q00005 ## Belongs to the phosphatase 2A regulatory subunit B family. & Contains 7 WD repeats. View All» Brand Family: Upstate View All» Product Name: Anti-PP2A Antibody, B' subunit | 07-334 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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