金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ala22-Gly271 & Arg107-Gly271, both with a C-terminal 6-His tag Accession #:Q63366 N-terminal Sequence Analysis:Ala22 & Arg107 Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:19 kDa & 29.4 kDa SDS-PAGE:27-30 kDa and 42-50 kDa, reducing conditions Activity:Measured in a competitive binding assay. When rrNeurexin-1 alpha (R&D Systems, Catalog# 4485-NX) is immobilized at 1 µg/mL (100 µL/well), rrNeurexophilin-1 inhibits 50%binding of biotinylated rrNeurexophilin-1 (1 µg/mL) at the concentration range of 1 - 3 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Neurexophilin-1 Aliases: NPH1; NXPH1 Entrez Gene IDs: 30010 (Human); 18231 (Mouse); 25501 (Rat) Background: Neurexophilin Family Neurexophilins (NXPH) are a family of neuropeptide-like secreted glycoproteins expressed in specific regions of the brain. NXPH1 is expressed mainly by cells that resemble inhibitory interneurons, while NXPH3 is found selectively in subplate-derived neurons in cortical layer 6b, granule cells in the vestibulocerebellum and Cajal-Retzius cells during development. NXPH1, 2 and 3 are tightly bound extracellular ligands of alpha-neurexins, synaptic transmembrane molecules that are essential for calcium-triggered neurotransmitter release. NXPH2 is not expressed in rodents, and NXPH4 does not bind alpha-neurexins.