货号：07-371

品牌：Merck Millipore

规格：200Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone H2B Antibody | 07-371 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes and is specific for Histone H2B, MW ~15 kDa. An additional band at ~23 kDa is detected in some samples, which likely corresponds to ubiquityl-Histone H2B. View All» Molecular Weight: ~15 kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 118-126 (CG-AVTKYTSSK) of human Histone H2B, with an N-terminal CG added for conjugation purposes. View All» Isotype: IgG View All» Background Information: Histone H2B is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H2A is involved with the structure of the nucleosomes of the 'beads on a string' structure. View All» Species Reactivity:

• Chicken

• Xenopus

• Human

• Yeast (S. cerevisiae)
  View All» Species Reactivity Note: Human, chicken, yeast and Xenopus. Others not tested. Broad species cross-reactivity expected based on sequence homology. View All» Application Notes: Chromatin Immunoprecipitation (ChIP): A previous lot of this antibody was used in ChIP. View All» Control: Acid extract from either sodium butyrate or colcemid treated HeLa cells. View All» Quality Assurance: Evaluated by western blot on acid extracts from either sodium butyrate or colcemid treated HeLa cells.Western Blot Analysis: A 1:1,000-1:10,000 dilution of this antibody detected Histone H2B in acid extracts from either sodium butyrate or colcemid treated HeLa cells (Catalog # 13-113 and 13-114 respectively), chicken core histone (Catalog # 13-107) and recombinant human Histone H2B (Catalog # 14-491). Recombinant Xenopus Histone H2B (Catalog # 14-410) was used with a previous lot. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit polyclonal in buffer containing 0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and 0.1% sodium azide, and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q8N257 View All» Entrez Gene Number: NP_778225 View All» Gene Symbol:
  • GL105

  • H2B

  • H2B-GL105

  • H2B.1

  • H2B.q

  • H2B/q

  • H2BFQ

  • MGC119802

  • MGC119804

  • MGC129733

  • MGC129734

  • OTTHUMP00000013920
    View All» Alternate Names:
    • H2B

    • Histone H2B

    • H2B histone family, member Q

    • histone 2, H2be

    • histone cluster 2, H2be
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. View All» UniProt Summary: FUNCTION: SwissProt: Q8N257 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SIZE: 126 amino acids; 13908 Da SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus.PTM: Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. & Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class- switch recombination.SIMILARITY: SwissProt: Q8N257 ## Belongs to the histone H2B family. View All» Brand Family: Upstate View All» Product Name: Anti-Histone H2B Antibody | 07-371 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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