货号：07-415

品牌：Merck Millipore

规格：200UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sam 68 Antibody | 07-415 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Sam 68 View All» Molecular Weight: 68kDa View All» Immunogen: Peptide corresponding to residues 331-348 of human Sam 68 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from HeLa cells View All» Purification Method: Antiserum View All» Presentation: 0.1M Trisglycine,pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q07666 View All» Entrez Gene Number: NM_006559 View All» Gene Symbol:
  • KHDRBS1

  • Sam68

  • FLJ34027

  • SAM68

  • p68

  • p62
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: Q07666 # Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.SIZE: 443 amino acids; 48227 Da SUBUNIT: Self-associates to form homo-oligomers when bound to RNA, oligomerization appears to be limited when binding to proteins. Interacts with CBL, KHDRBS3, LCK, GRB2, JAK3, PIK3R1, PLCG1, PTPN6, RASA1, and STAT3. Interacts with PRMT1. Binds the WW domains of WBP4/FBP21, FNBP4/FBP30 and the SH3 domain of FYN through the Arg/Gly-rich-flanked Pro-rich regions (By similarity).SUBCELLULAR LOCATION: Nucleus. Membrane.TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.DEVELOPMENTAL STAGE: Isoform 3 is only expressed in growth- arrested cells.DOMAIN: SwissProt: Q07666 The KH domain is required for binding to RNA (By similarity). & The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methlylation on these motifs can modulate protein-protein interactions (By similarity).PTM: Tyrosine phosphorylated by several non-receptor tyrosine kinases, for example LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. & Acetylated. Positively correlates with ability to bind RNA. & Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30. & Arg-291, Arg-331 and Arg-346 are found to be also dimethylated, probably to asymmetric dimethylarginine.SIMILARITY: Belongs to the KHDRBS family. & Contains 1 KH domain. View All» Brand Family: Upstate View All» Product Name: Anti-Sam 68 Antibody | 07-415 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-135660.htm
      © Merck Millipore代理07-415 Anti-Sam 68 Antibody;抗-Sam 68抗体store at -20℃，产品报价联系微信jinshanbio