货号：07-447

品牌：Merck Millipore

规格：

目录价：￥4749.00

市场价格：￥4036.65

会员价格：￥3799.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Acinus Antibody, NT | 07-447 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Acinus-L, Mr ~220kDa. A non-specific protein was also detected, Mr ~55 kDa. View All» Molecular Weight: 220kDa View All» Epitope: a.a. 1-104 View All» Immunogen: The immunogen was a GST fusion protein corresponding to residues 1-104 of human Acinus-L. View All» Background Information: Acinus (Apoptotoic Chromatin condensation Inducer in the NUcleuS) is a ubiquitously expressed nuclear factor that is essential for apoptotic chromatin condensation. The ~220 kDa acinus protein is cleaved by caspase-3 and an additional unidentified protease to release a 17 kDa fragment that induces chromatin condensation in vitro. Acinus is expressed in three isoforms, AcinusL, AcinusS, and Acinus Sˊ, with the two shorter isoforms (~100 kDa) constituting the C-terminal region of the longer form. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Not yet tested in other species. The immunogen sequence is 90 and 93% homologous in mouse and rat, respectively. View All» Control: Includes Positive Antigen Control, Cat. #12-303, Jurkat lysate. Add 2.5 μl of 2-mercaptoethanol/100 μl of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels. View All» Quality Assurance: Western Blot Analysis: 1.0 μg/ml of this antibody detected Acinus-L in Jurkat cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Supplied as 200 μg of affinity purified rabbit IgG in 200 μl of 0.1M Tris-glycine, pH 7.4, 150 mM NaCl, 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: Q9UKV3 View All» Entrez Gene Number: NM_014977 View All» Gene Symbol:

• ACIN1

• ACINUS

• KIAA0670

• Acinus

• ACN

• DKFZp667N107
  View All» Alternate Names:
  • apoptotic chromatin condensation inducer 1

  • apoptotic chromatin condensation inducer in the nucleus

  • functional spliceosome-associated protein 152
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q9UKV3 # Induces apoptotic chromatin condensation after activation by CASP3.SIZE: 1341 amino acids; 151888 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous.PTM: Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.SIMILARITY: SwissProt: Q9UKV3 ## Contains 1 SAP domain. View All» Brand Family: Upstate View All» Product Name: Anti-Acinus, NT View All» Concentration: 1 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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