货号：07-466

品牌：Merck Millipore

规格：EA

目录价：￥3550.00

市场价格：￥3017.50

会员价格：￥2840.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PPARγ Antibody | 07-466 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes PPARγ1 and 2, Mr 55-60 kDa. A non-specific protein was also detected, Mr 47 kDa after longer exposure. View All» Molecular Weight: ~67 kDa View All» Immunogen: KLH-conjugated, synthetic peptide (GEDKIKFKHITPLQEQ) corresponding to amino acids 256-271 of human PPARγ1 and amino acids 287-302 of human PPARγ2. The immunizing sequence is identical in mouse and rat. View All» Isotype: IgG View All» Background Information: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes where it regulates the expression of proteins involved in fatty acid metabolism. PPARβ is the most widely distributed subtype and is often expressed at high levels. PPARγ is predominantly seen in adipose tissue where it plays a critical role in regulating adipocyte differentiation. View All» Species Reactivity:

• Human

• Mouse

• Vertebrates

• Pig

• Rabbit

• Rhesus Macaque

• Mink

• Rat
  View All» Species Reactivity Note: Human and mouse. Predicted to cross-react with rat, pig, rabbit, rhesus monkey, mink and other vertebrates based on sequence conservation. View All» Control: Human breast carcinoma tissue, rat skeletal muscle extract or U-937 cell lysate. View All» Quality Assurance: Evaluated by western blot in RIPA lysates from 3T3/L1 cells differentiated into adipocytes.Western Blot Analysis: 1-5 μg/mL of this antibody detected PPARγ protein in RIPA lysates from 3T3/L1 cells differentiated into adipocytes but not in undifferentiated 3T3/L1 cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q53EW1 View All» Entrez Gene Number: NP_005028.4 View All» Gene Symbol:
  • PPARA

  • PPAR

  • hPPAR

  • MGC2452

  • OTTHUMP00000042872

  • OTTHUMP00000028713

  • NR1C1

  • PPAR-alpha

  • MGC2237
    View All» Alternate Names:
    • Nuclear receptor subfamily 1 group C member 1

    • peroxisome proliferative activated receptor, alpha

    • peroxisome proliferator activated receptor alpha

    • peroxisome proliferator-activated receptor alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q07869 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.SIZE: 468 amino acids; 52225 Da SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13 (By similarity).SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Skeletal muscle, liver, heart and kidney.SIMILARITY: SwissProt: Q07869 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-PPARγ Antibody | 07-466 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-135795.htm
      © Merck Millipore代理07-466 ANTI-PPAR GAMMA 200UG，产品报价联系微信jinshanbio