货号：07-468

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HuR Antibody | 07-468 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: HuR View All» Molecular Weight: ~36 kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 1-13 of human HuR. View All» Background Information: HuR (Hu-antigen R, ELAV-like protein 1, ELAV1) is an RNA binding protein that contains 3 RNA-binding domains. It is known to binds AU-rich elements if mRNA. It regulates gene expression by destabilizing their mRNA. It is known to be upregulated in certain cancers such as breast and gastric cancers. Some of its targets include cFos, IL-3, and BRCA1 mRNAs. HuR has also been shown to be involved in the regulation of VEFG-A and NFkB expression in certain cell types. It activation and accumulation are also linked to many energy signaling molcules such as that of the PI3K/Akt pathway and AMPK.. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a representative lot detected HuR in RIPA lysate.Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected HuR in HeLa and NIH/3T3 cell lysates.Immunohistochemistry Analysis: This antibody has been reported by an independent laboratory to detect HuR in rabbit placental tissue. View All» Control: 3T3/A31 cell lysate View All» Quality Assurance: Western Blot Analysis: Evaluated by Western Blot in 3T3/A31 cell lysate using 1 µg/mL of antibody and 10 µg of lysate. View All» Purification Method: See datasheet for specific purification method. View All» Presentation: See datasheet for exact formulation. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q15717 View All» Entrez Gene Number: NP_001410 View All» Gene Symbol:
  • ELAVL1

  • MelG

  • HUR

  • ELAV1

  • HuR

  • Hua
    View All» Alternate Names:
    • ELAV-like protein 1

    • Hu-antigen R
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression. View All» UniProt Summary: FUNCTION: SwissProt: Q15717 # Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs.SIZE: 326 amino acids; 36092 Da SUBUNIT: Interacts with ANP32A.TISSUE SPECIFICITY: Ubiquitous.PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.SIMILARITY: SwissProt: Q15717 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains. View All» Brand Family: Upstate View All» Product Name: Anti-HuR Antibody | 07-468 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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