金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Val22-Ser1268 (Tyr703Ser & Thr1241Met), with a C-terminal 10-His tag Accession #:Q6YHK3 N-terminal Sequence Analysis:Val22 Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:141 kDa SDS-PAGE:155-165 kDa, reducing conditions Activity:Measured by its ability to bind TGF-beta 1 in a functional ELISA. Finnson, K.W. etal. (2006) FASEB J. 20:1525.Immobilized rhTGF-beta 1 at 1 µg/mL (100 µL/well) can bind rhCD109 with an apparent K_D < 0.1 µM. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: CD109 Aliases: CD109; CPAMD7 Entrez Gene IDs: 135228 (Human); 235505 (Mouse); 363104 (Rat) Background: CD109 View CD109 IHC images. CD109 is a GPI-anchored member of the alpha-2-macroglobulin (A2M) and complement family of proteins. CD109 is expressed on activated T cells and platelets, hematopoietic stem cells, megakaryocyte precursors, vascular endothelial cells, basal and myoepithelial cells of secretory glands, and squamous cell carcinoma. Human CD109 is produced as a 170 kDa - 180 kDa glycoprotein that is autocatalytically processed to 150 kDa and 120 kDa forms. CD109 on keratinocytes binds TGF-beta and associates with TGF-beta RI and TGF-beta RII, resulting in inhibition of TGF-beta signaling. Polymorphisms of CD109 include the platelet-specific Gov antigen and the blood group ABH antigens. Alloantibodies directed against these antigens result in unsuccessful platelet transfusions, neonatal alloimmune thrombocytopenia, and posttransfusion purpura.