货号：07-478

品牌：Merck Millipore

规格：200Ul

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SNF2β/BRG1 Antibody | 07-478 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: The SNF2 family of proteins are ATP dependant chromatin remodeling enzymes. The gene encoding this protein is also refered to as SMARCA4. View All» Specificity: This antibody recognizes the Near N-Terminus of SNF2B View All» Molecular Weight: 200 kDa View All» Immunogen: GST-tagged recombinant protein corresponding to the Near N-Terminus of human SNF2β. View All» Isotype: IgG View All» Background Information: The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: HeLa Nuclear Extract. View All» Quality Assurance: Evaluated by Western Blotting in HELA NE cell lysate.Western Blotting Analysis: A 1:4,000 dilution of this antibody detected SNF2B/BRG1 in 10 µg of HELA NE cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal in buffer containing with 0.05% sodium azide with 30% glycerol. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P51532 View All» Entrez Gene Number: NM_003072 View All» Gene Symbol:
  • SMARCA4

  • BRG1

  • SNF2B

  • SNF2L4
    View All» Alternate Names:
    • Probable global transcription activator SNF2L4

    • ATP-dependent helicase SMARCA4

    • SNF2-beta

    • BRG-1

    • Mitotic growth and transcription activator

    • Brahma protein homolog 1

    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P51532 # Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.SIZE: 1647 amino acids; 184646 Da SUBUNIT: Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: P51532 ## Belongs to the SNF2/RAD54 helicase family. & Contains 1 bromo domain. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 1 HSA domain. View All» Brand Family: Upstate View All» Product Name: Anti-SNF2β/BRG1 Antibody | 07-478 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μL View All» Format: Serum View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-135827.htm
        © Merck Millipore代理07-478 Anti-SNF2β/BRG1 Antibody;抗SNF2β / BRG1抗体store at -20℃，产品报价联系微信jinshanbio