货号：07-496

品牌：Merck Millipore

规格：

目录价：￥4505.00

市场价格：￥3829.25

会员价格：￥3604.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myeloperoxidase Antibody | 07-496 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: myeloperoxidase subunits and glycosylated precursor View All» Molecular Weight: subunits (12 & 60kDa); precursor (92kDa) View All» Immunogen: Purified protein from human neutrophil granules View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from HL-60 cells View All» Purification Method: Antiserum View All» Presentation: 0.05% sodium azide and 30% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P05164 View All» Entrez Gene Number: NM_000250 View All» Gene Symbol:
  • MPO

  • myeloperoxidase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. View All» UniProt Summary: FUNCTION: SwissProt: P05164 # Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.COFACTOR: Binds 1 calcium ion per heterodimer. & Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.SIZE: 745 amino acids; 83869 Da SUBUNIT: Tetramer of two light chains and two heavy chains.SUBCELLULAR LOCATION: Lysosome.DISEASE:SwissProt: P05164 # Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.SIMILARITY: SwissProt: P05164 ## Belongs to the peroxidase family. XPO subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Myeloperoxidase Antibody | 07-496 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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