金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Arg29-Ser513, with an N-terminal signal peptide and a C-terminal 6-His tag Accession #:AAC08702 N-terminal Sequence Analysis:Arg29 Structure:Pro & Mature. Recombinant Human ADAM12 is prone to proteolytic clevage at C-terminus. The predominant form of the purified protein lacks the His tag. Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:55 kDa (Pro) & 34 kDa (Mature) SDS-PAGE:28 kDa, 44 kDa &68 kDa, reducing conditions Activity:Measured by its ability to cleave IGFBP-3. Formulation:Supplied as a 0.2 µm filtered solution in HEPES, NaCl and CaCl₂.See Certificate of Analysis for details. Molecule Information: ADAM12 Long Name: A Disintegrin and Metalloprotease-like Domain 12 Aliases: Meltrin alpha Entrez Gene IDs: 8038 (Human) Background: ADAMs (A Disintegrin and Metalloprotease) Members of the ADAM or MDC (Metalloprotease, Disintegrin, Cysteine-rich) family contain pro, metalloprotease-like, disintegrin-like, cysteine-rich, transmembrane and cytoplasmic domains. They play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. Over 30 members have been identified and about half of them are active metalloproteases such as ADAM8, 9, 10, 12 and 17/TACE.