货号：07-535

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MKP1 Antibody | 07-535 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes MKP1. View All» Molecular Weight: 42 kDa View All» Immunogen: peptide corresponding to amino acids 87-101 (DERSAALDGAKRDGT-C) of human MAP kinase phosphatase 1 (MKP1) View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Control: Positive Control Included: 3T3 Cell Lysate (12-305) View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from 3T3/A31 cells View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P28562 View All» Entrez Gene Number: NM_004417 View All» Gene Symbol:
  • DUSP1

  • VH1

  • YVH1

  • HVH1

  • MKP1

  • MKP-1

  • PTPN10

  • CL100
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. View All» UniProt Summary: FUNCTION: SwissProt: P28562 # Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.SIZE: 367 amino acids; 39298 Da TISSUE SPECIFICITY: Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.SIMILARITY: SwissProt: P28562 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 rhodanese domain. & Contains 1 tyrosine-protein phosphatase domain. View All» Brand Family: Upstate View All» Product Name: Anti-MKP1 Antibody | 07-535 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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