金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:Q9P1W8 N-terminal Sequence Analysis:Val64 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:60 kDa SDS-PAGE:68-75 kDa, reducing conditions Activity:Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/mL anti-CD3 and rhSIRP gamma.The ED₅₀ for this effect is typically1 - 6 µg/mL.Optimal dilutions should be determined by each laboratory for each application. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: SIRP gamma/CD172g Long Name: Signal-regulatory Protein gamma Aliases: CD172g; SIRP beta 2; SIRPG Entrez Gene IDs: 55423 (Human) Background: SIRP gamma/CD172g Signal regulatory protein gamma (SIRP gamma, designated CD172g), also called SIRP beta 2, is a type I transmembrane protein belonging to the SIRP/SHPS (CD172) family within the Ig superfamily. SIRP gamma is expressed on T cells, CD56bright NK cells and activated NK cells, but not myeloid cells. Like SIRP alpha, it binds CD47, but unlike SIRP alpha, it does not contain an obvious signaling mechanism. T cell SIRP gamma may play a role as an accessory protein interacting with CD47-expressing antigen presenting cells, and appears to promote antigen-specific T cell proliferation and costimulate T cell activation.