货号：07-557

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRK1 Antibody | 07-557 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: PRK1 View All» Molecular Weight: 130kDa View All» Immunogen: peptide corresponding to amino acids 918-930 (C-PRDARPLTAAEQA) of human Protein Kinase C Related Protein Kinase 1 (PRK1). View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from Jurkat, HeLa, HEK293 and A549 cells View All» Purification Method: Protein A purfied View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q16512 View All» Entrez Gene Number: NM_002741 View All» Gene Symbol:

• PKN1

• PRKCL1

• DBK

• PRK1

• PAK1

• PKN

• MGC46204
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q16512 # Can phosphorylate ribosomal protein S6. Mediates GTPase Rho dependent intracellular signaling (By similarity).SIZE: 942 amino acids; 103990 Da SUBUNIT: Interacts with ZA20D3 (By similarity). Interacts with RhoA and Rac1.SUBCELLULAR LOCATION: Cytoplasm (By similarity).TISSUE SPECIFICITY: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.DOMAIN:SwissProt: Q16512 The C1 domain does not bind the diacylglycerol (DAG).PTM: Autophosphorylated; preferably on serine. & Activated by limited proteolysis with trypsin (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats. View All» Brand Family: Upstate View All» Product Name: Anti-PRK1 Antibody | 07-557 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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