货号：07-582-I

品牌：Merck Millipore

规格：200UL

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-IRF-3 (Ser396) Antibody | 07-582-I View All» Replaces: 07-582 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IRF-3 phosphorylated at Ser396. View All» Molecular Weight: ~50 kDa observed. Uncharacterized bands may appear at ~40 kDa and ~80 kDa in some lysates. View All» Epitope: SNS → ANA: Mutation of this residue results in loss of viral-induced phosphorylation of IRF-3. View All» Immunogen: KLH-conjugated linear peptide corresponding to human IRF-3 phosphorylated at Ser396. View All» Background Information: Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal serine and threonine residues (between 385 and 405) leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rhesus Macaque and Porcine based on 100% sequence homology. View All» Control: Untreated and sendai virus treated A549 cell lysates View All» Quality Assurance: Evaluated by Western Blot in untreated and sendai virus treated A549 cell lysates.Western Blot Analysis: A 1:1,000 dilution of this antibody detected phospho-IRF-3 (Ser396) in 10 µg of sendai virus treated A549 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14653 View All» Entrez Gene Number: NP_001562 View All» Gene Symbol: IRF3 View All» Alternate Names:

• Interferon regulatory factor 3

• IRF-3
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-phospho-IRF-3 (Ser396) View All» Concentration: 0.2 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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