金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala106-Tyr131 (A chain) & Leu21-Ala55 Accession #:P51460 N-terminal Sequence Analysis:Ala106 (A chain) & Leu21(B chain) Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:2.8 kDa (A chain), 3.9 kDa (B chain) Activity:Measured by its ability to induce cAMP accumulation in HEK293 human embryonic kidney cells transfected with human RXFP2. Halls, M.L. et al. (2006) Mol. Pharmacol. 70:214.The ED₅₀ for this effect is typically 12.5-50 pg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: INSL3 Long Name: Insulin-like 3 Aliases: Ley I-L; RLF; RLNL Entrez Gene IDs: 3640 (Human); 16336 (Mouse); 114215 (Rat) Background: INSL3 INSL3 (insulin-like 3), formerly called Ley I-L (Leydig cell insulin-like), is a member of the insulin/relaxin superfamily. INSL-3 is a secreted protein produced by testicular Leydig cells and in lower amounts by ovarian follicular theca interna cells and the corpus luteum. The receptor for INSL-3 is the leucine-rich G-protein coupled receptor LGR8, also called RXFP2 or GREAT. Deletion of either INSL3 or LGR8 in the mouse causes failure of the testes to descend (cryptorchidism). Mutation of INSL3 is also an occasional cause of cryptorchidism in humans.