货号：07-584

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HMGB1/HMG-1 Antibody | 07-584 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes HMGB1/HMG-1, MW ~32 kDa. View All» Molecular Weight: ~32 kDa View All» Immunogen: HMGB1/HMG-1 protein purified from pig thymus glands. View All» Isotype: IgG View All» Background Information: HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1, identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Broad species cross-reactivity is expected. View All» Control: Acid extracted proteins from HeLa cells. View All» Quality Assurance: Evaluated in acid extracted proteins from HeLa cells.Western Blot Analysis: 1-2 μg/mL of this antibody detected HMGB1/HMG-1 in acid extracted proteins from HeLa cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P09429 View All» Entrez Gene Number: NP_002119 View All» Gene Symbol:

• HMGB1

• HMG1

• Amphoterin

• DKFZp686A04236

• HMG3

• SBP-1
  View All» Alternate Names:
  • High mobility group protein 1

  • Sulfoglucuronyl carbohydrate binding protein

  • high mobility group box 1

  • high-mobility group (nonhistone chromosomal) protein 1

  • high-mobility group box 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P09429 # Binds preferentially single-stranded DNA and unwinds double stranded DNA.SIZE: 215 amino acids; 24894 Da SUBCELLULAR LOCATION: Nucleus.SIMILARITY: SwissProt: P09429 ## Belongs to the HMGB family. & Contains 2 HMG box DNA-binding domains. View All» Brand Family: Upstate View All» Product Name: Anti-HMGB1/HMG-1 Antibody | 07-584 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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